Pancreatic cancer(PC)is one of the most aggressive human malignancies worldwide and is the fourth leading cause of cancer-related deaths.Curcumin(diferuloylmethane)is a polyphenol derived from the Curcuma longa plant.Certain studies have demonstrated that curcumin exerts its anti-tumor function in a variety of human cancers including PC,via targeting multiple therapeutically important cancer signaling pathways.