Benefit of metformin in human esophageal carcinoma:preclinical studies and clinical trials

来源 :2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：zengguiyeah3

【摘要】

：

【作者】

：

Yusheng Lin Liang Du Hongcai Chen Shaobin Chen Gen Wang Yi Guo Yuping Chen Sai-Ching Jim Yeung Hao Zhang

【机构】

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Cancer Research Center,Shantou University Medical College,Shantou,Guangdong,China

【出处】

：

2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会

【发表日期】

：

2016年10期

【关键词】

：

Esophageal squamous cell carcinoma Metformin proliferation clinical trials

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　　Aim: The anti-diabetic drug metformin exerts chemopreventive and antineoplastic effects in many types of malignancies.We previously described the in vitro and in vivo effects of metformin on esophageal squamous cell carcinoma(ESCC).The studies of mechanisms indicated that STAT3 inactivation and Bcl-2 repression contribute to metformin-induced growth inhibition of ESCC by facilitating crosstalk between apoptosis and autophagy.

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Benefit of metformin in human esophageal carcinoma:preclinical studies and clinical trials

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