Aurora kinase A has been demonstrated to be involved in the malignant progression of many types of cancer,as its amplification and up-regulation could induce the chromosomal instability [1].Thus,it could be used as a good target for cancer therapy,especially decreasing its expression level through oligonucleotide technology.Among the oligonucleotides,DNAzyme is an attractive therapeutic one which enables the cleavage of mRNA in a sequence-specific manner for silencing the target genes.A great challenge in the down-regulation of gene expression using DNAzymes is to construct safe and efficient carriers for delivering them to targeted disease sites and cells [2].