miR-125b contributes BBB and cognitive dysfunction in presenilin1/2 conditional knock-out mice throu

来源 :长三角地区神经科学论坛暨浙江省神经科学学会2014年年会 | 被引量 : 0次 | 上传用户:ck101newguy
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  With the increasing average lifespan,the incidence of Alzheimers disease(AD)has an alarming rise.AD is a neurodegenerative disease of the elderly that results in progressive memory loss and cognitive decline.The main pathological hall markers of AD are intracellular neurofibrillary tangles,extracellular β-amyloid(Aβ)plaques and neuro death,in addition,the blood brain barrier(BBB)has different degrees of defect.
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