Regulation of host cell gene expression and cell cycle progression by nsp11 of PRRS virus

来源 :2013国际猪繁殖与呼吸综合征学术研讨会 | 被引量 : 0次 | 上传用户：aaronlonghao

【摘要】

：

Non-structural protein 11 (nsp 11) of porcine reproductive and respiratory syndrome virus (PRRSV) is a vial endoribonuclease that is essential for infectivity with an unknown mechanism.To examine the

【作者】

：

Y.Sun D.Li S.Giri S.G.Prasanth D.Yoo

【机构】

：

Department of Pathobiology,University of Illinois at Urbana-Champaign, Urbana, IL, USA

【出处】

：

2013国际猪繁殖与呼吸综合征学术研讨会

【发表日期】

：

2013年12期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Non-structural protein 11 (nsp 11) of porcine reproductive and respiratory syndrome virus (PRRSV) is a vial endoribonuclease that is essential for infectivity with an unknown mechanism.To examine the cellular gene expression profiles regulated by nspl 1,MARC-nspll cells were established by retrovirus-mediated gene transfer to constitutively express the nspl 1 protein.Gene integration and protein expression were confirmed by PCR,RT-PCR,and Western blot analysis using anti-nsp 11 antiserum raised in a rabbit.

其他文献

Co-infection study between porcine reproductive and respiratory syndrome virus and a bacteria led to

Main objective:Study the effect of a pre-viral infection with porcine reproductive and respiratory syndrome virus (PRRSV) on a bacterial infection by Actinobacillus pleuropneumoniae (App) in vitro.Spe

会议

Dissection for the structure and function of a 5'-proximal prominent stem-loop in Porcine Repro

Introduction Like other arteriviruses,PRRSV 5 UTR is believed to carry a variety of cis-acting elements that regulate the discrete steps of viral life cycle.But the regulatory function and mechanism n

会议

Impact of co-infection by porcine circovirus (PCV) and porcine reproductive and respiratory syndrome

Main objective:The main goal of this research is to study the impact of PRRSV/PCV co infections in a new cellular model,the NPTr-CD 163 cells.Specific objectives:-Test NPTr-CD163 cells for permissivit

会议

表达猪2型圆环病毒Cap蛋白重组支气管败血波氏杆菌作为猪圆环病毒候选疫苗的初步研究

目的将猪2型圆环病毒(PCV2) ORF2基因重组支气管败血波氏杆菌(Bb),获得能表达猪2型圆环病毒Cap蛋白的减毒支气管败血波氏杆菌,针对猪2型圆环病毒引起的猪多系统功能障碍性疾病,开发一种新型疫苗,利用Bb能在猪呼吸道黏膜上皮细胞有效和有限地定殖并激发黏膜免疫的能力,将PCV2的免疫原性蛋白通过呼吸道途径进行免疫,从而达到预防PCV2的感染,为该重组菌株作为候选疫苗提供科学依据.

会议

Signal peptide cleavage from GP5 of PRRSV: Only a minor subfraction of molecules retains the decoy e

GP5,the major glycoprotein of PRRSV,is considered as one possible target of neutralizing antibodies,which however appear only late in infection.This was attributed to the presence of a "decoy epitope"

会议

Non-structural protein 2 of the porcine reproductive and respiratory syndrome (PRRS) virus: a crucia

Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of significant economic importance that causes reproductive and respiratory problems in pigs.The replicase non-structural protei

会议

The effect of the position of N-linked glycosylation sites within hypervariable region of GP5 on vir

Introduction N-linked glycosylation of the GP5 protein is involved in diverse functions such as virus infectivity,receptor binding and immune response.Potential N-glycosylation sites were observed at

会议

Role of non-structural protein 2 in the regulation of the replication of the porcine reproductive an

Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease in swine-producing areas.Many vaccine strategies have been developed to control the disease,but none have yet

会议

Concurrent highly pathogenic porcine reproductive and respiratory syndrome virus infection accelerat

The study was aimed at determining the effect of HP-PRRSV on HPS in co-infection.The infB gene,which is conserved among different HPS serotypes and different species,was amplified using PCR from extra

会议

The host miR-26a inhibits porcine reproductive and respiratory syndrome virus replication by activat

Porcine reproductive and respiratory syndrome (PRRS) has caused large economic losses in the swine industry in recent years.Cunrent PRRS vaccines not effectively prevent and control this disease.Conse

会议

Regulation of host cell gene expression and cell cycle progression by nsp11 of PRRS virus

与本文相关的学术论文