Prion Diseases and Emerging Prion Diseases

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户：xiaofeidong

【摘要】

：

　　Transmissible spongiform encephalopathies (TSES),also called prion diseases,are fatal neurodegenerative disorders.An abnormal isoform of the prion protein (

【作者】

：

Takashi Yokoyama

【机构】

：

PrionDiseaseResearchCenterNationalInstituteofAnimalHealthJapan

【出处】

：

2008中国深圳蛋白质和多肽科学大会

【发表日期】

：

2008年4期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Transmissible spongiform encephalopathies (TSES),also called prion diseases,are fatal neurodegenerative disorders.An abnormal isoform of the prion protein (PrPSc) generated by post-translational modification of the cellular prion protein (PrPC) is believed to be the main component of this infectious agent.PrPSc is relatively resistant to proteinase K (PK) digestion.This characteristic has been widely accepted as the physicochemical basis for distinguishing between PrPC and PrPSc.PrPC is a glycoprotein that contains 2 Asn-linked glycosylation sites; it is present in the cells in 3 different glycoforms,including an unglycosylated form.

其他文献

Design and Characterization of PeptidesDepsipeptides as Anticancer Agents

　　Several naturally occurring peptides and depsipeptides which include the cryptophycins,dolastatin 10,hemiasterlin,and phomopsin A have been found to be pote

会议

Targeting PYK2 and Its Protein-protein Interactions in the Integrin Signaling Pathway for Anti-cance

　　Proline-rich tyrosine kinase 2 (PYK2) is a non-receptor protein tyrosine kinase.As a major adhesion kinase and adaptor molecule in the integrin signaling pa

会议

Chemical Engineering of Insulin by Acylation with Either Fatty Acids or Derivatives of Cholic Acid R

　　Treatment of diabetes by s.c.injections of insulin co-crystallized together with protamine (NPH-insulin) or as insulin zinc crystals together with amorphous

会议

Structure-Guided Transformation of Proteins into Small Molecule Leads

　　Proteins serve crucial functions in essentially all biological processes,but lack appropriate physical chemical properties and metabolic stability to be ide

会议

Lunasin,a Novel and Unique Cancer Preventive Seed Peptide that Inhibits Core Histone Acetylation and

　　The high incidence and mortality and generally lack of effective treatment for cancer have spurred extensive research on chemoprevention.Natural substances

会议

Validation and Integration of Protein 3D Structure Information

　　Many international projects of Structural Genomics/Structural Proteomics have now made it possible to determine protein three-dimensional (3D) structures mu

会议

ErbB Inhibitory Protein [EBIP]A Modified Ectodomain of Human Egfr is a Potential Anticancer Agent

　　The EGF-receptor (EGFR) consists of an extracellular ligand-binding domain,a hydrophobic transmembrane region,and an intracellular tyrosine kinase domain.Th

会议

‘Silencing’a Cell Penetrating Peptide Using Hydropobhic Anchors

　　In general,small peptide sequences taken from proteins do not display a particular fold on the basis of their primary amino acid sequence and are therefore

会议

Progress in Development of Anti-cancer Drugs without Unwanted Side Effects

　　Cytotoxic agents generally display little or no specificity,although cancer chemotherapy requires the preferential killing of rapidly proliferating tumor ce

会议

Discovery of Protein Biomarkers to Predict Early Stage Non-small Cell Lung Cancer Recurrence

　　Purpose:More than half of stage I non-small cell lung cancer (NSCLC) patients will relapse,suggesting that many patients have undetectable metastasis at the

会议

Prion Diseases and Emerging Prion Diseases

与本文相关的学术论文