Predictors for Dose Reductions Caused by Hematological Adverse Events in Patients with Advanced Fibr

来源 :中华医学会第六次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议 | 被引量 : 0次 | 上传用户:lw8307817
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Objectives To describe hematological adverse events (AE) and explore predictors for dose reduction caused by hematological AE in patients with advanced fibrosis receiving pegylated interferon plus ribavirin for chronic hepatitis C (CHC) Methods MEDLINE, EMBASE, Web of Science, and The Cochrane library were searched for randomized clinical trials and observational studies reporting hematological AE associated with pegylated interferon plus ribavirin for CHC in patients with stage 3 or 4 fibrosis.Qualified studies were reviewed to extract patients baseline characteristics, disease information, treatment information, and clinical outcomes including incidence and grade of hematologic AE, dose reduction and treatment discontinuation due to hematological AE, and sustained viral response (SVR).
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