TRPP2 physically associates with STIM1: the role in store operated Ca2+ entry to regulate blood vess

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：baiyunmtq

【摘要】

：

Rationale: Polycystin-2 (TRPP2) as a Ca2+ permeable nonselective cationic channel executes crucial physiological function in live cells.The stromal interaction molecule 1 (STIM1) is an important Ca2+

【作者】

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Muyao Zhou Jin Zhang Gongliang Zhang Juan Du Bing Shen Ren Zhao Kunli Su Juncheng Hu Yong Ye Jie Li Yan Li Feifei Jiang Jinhang Zhu

【机构】

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Anhui Medical University, Hefei, China

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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TRPP2 STIM1 store-operated Ca2+entry vascular smooth muscle cells vessel

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Rationale: Polycystin-2 (TRPP2) as a Ca2+ permeable nonselective cationic channel executes crucial physiological function in live cells.The stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-operated Ca2+ entry (SOCE).Both TRPP2 and STIM1 express in the membrane of endoplasmic reticulum involving Ca2+ signal in live cells.Objective: We tested the hypothesis that TRPP2 interacts with STIM1 to regulate SOCE and investigated the functional role of the interaction in vascular smooth muscle cells (VSMCs).

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TRPP2 physically associates with STIM1: the role in store operated Ca2+ entry to regulate blood vess

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