【摘 要】
：
Mastitis is a major cause of economic losses to the dairy industry.Selenium (Se), a biological trace essential element, benefits health and immunity of the mammary gland.In the present study, we inves
【机 构】
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Northeast Forest University, Harbin 150000,P.R.China;Jilin University, Changchun 130062,P.R.China
【出 处】
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中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
论文部分内容阅读
Mastitis is a major cause of economic losses to the dairy industry.Selenium (Se), a biological trace essential element, benefits health and immunity of the mammary gland.In the present study, we investigate that effects of dietary selenium on LPS-induced models of mammary mastitis in mouse.Eighty female BALB/c mice were randomly divided into three groups and fed with daily rations that contain 0.087 mg/(kg· BW), 0.15 mg/(kg·BW) and 1.5 mg/(kg· BW) sodium selenium.At the end of experiment, an intramammary infusion of LPS was used to establish models of mastitis in mouse.Histopathological analysis, enzymatic activity detection and expression of pro-inflammatory genes were conducted to study effects of dietary selenium on LPS-induced models of mammary mastitis in mouse.Results showed that selenium can affect the activity of glutathione peroxidase and mRNA expression of GPX1 and GPX4 of mammary gland in a dose dependent manner.Histopathological observation of mammary gland in models of mammary mastitis in mouse showed more infiltration of inflammatory cells.mRNA expression of TNF-α, IL-1β, IL-6, COX-2 and iNOS of mammary gland of Se-deficient group were higher than Se-adequate group.These results showed that Se can affect LPS-induced inflammatory responses of mammary gland.
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