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We are developing integrated analytical systems for healthcare that utilize inexpensive electronics for sample detection and manipulation.Such systems will find applications as tools for life science and in new diagnostics for molecular and cellular analysis.This talk describes the development of a new generation of miniature microfluidic systems, based on large area programmable digital microfluidics.Unlike conventional microfluidic systems that require pumps and valves to control liquids, digital microfluidics (DMF) employs Electro Wetting on Dielectric (EWOD) to manipulate and process nanolitre droplets of liquid using electric fields.