μ-opioid presynaptic inhibition of GABA release in rat ventrolateral orbital cortex neurons

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户:beautyyin123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Previous studies have indicated that the ventrolateral orbital cortex (VLO) is involved in modulation of nociception as part of an endogenous analgesic system consisting of the spinal cord-nucleus submedius (Sm)-VLO-periaqueductal gray (PAG)-spinal cord loop.Microinjection of morphine into the VLO depresses the rat tail-flick reflex and suggests that the GABAergic modulation may be involved in the VLO morphine-induced antinociception.To provide electrophysiological evidence for the GABAergic modulation mechanism,the present study examined whether the presynaptic μ-opioid activation inhibited release of the GABA neurotransmitter in rat VLO slices.
其他文献
会议
会议
会议
目的 观察模拟高原急性缺氧时大鼠视网膜中兴奋性神经递质谷氨酸的分布变化,探讨牛磺酸对视网膜Müller细胞的谷氨酸代谢功能的影响.方法 126只SD大鼠随机分为6组,平原对照组(Con)、平原牛磺酸组(Tau)、4 500米缺氧组(45H)、4 500米缺氧+牛磺酸组(45HT)、5 500米缺氧组(55H)和5 500米缺氧+牛磺酸组(55HT),分别以基础饲料和添加了2.4%牛磺酸的饲料喂养一
MAPKs are a family of important intracellular signaling molecules that transduce extracellular stimuli into intracellular responses in a wide variety of circumstances and controls cell function and su
以往的研究表明,皮层投射到丘脑的纤维数量约为丘脑至皮层的纤维数量的10倍,这一庞大的反馈网络在感觉加工过程中的作用越来越受到研究者的重视。已有视觉,听觉和躯体感觉系统的研究结果表明,皮层丘脑反馈能够使丘脑神经元的感受野变得敏锐,并且形成适合皮层加工的感觉信息。但是目前这一反馈调节对痛觉的影响有何影响尚不清楚。本研究采用了大鼠核团微量注射的方法,给予大鼠初级躯体感觉皮层足底代表区GABAA激动剂蝇蕈
The glutamate transporter-1 (GLT-1) exclusively expressed on the astrocytes which functions as a glutamate scavenger probably correlates with astrocytes activation.And astrocytes activation is involve
Previous studies have indicated that the ventrolateral orbital cortex (VLO) is involved in an endogenous analgesic system consisting of the spinal cord-nucleus submedius-VLO-periaqueductal gray-spinal