【摘 要】
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Chemoradiation is the treatment of choice for locally advanced head and neck squamous cell carcinoma (HNSCC).However, radioresistance, which contributes to
【机 构】
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Department of Biochemistry and Molccular Cell Biology, Key Laboratory of the Education Ministry for
【出 处】
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中国细胞生物学学会全体会员代表大会暨第十二次学术大会
论文部分内容阅读
Chemoradiation is the treatment of choice for locally advanced head and neck squamous cell carcinoma (HNSCC).However, radioresistance, which contributes to local recurrence, remains a significant therapeutic problem.In this study, we characterized SM-164, a small second mitochondria-derived activator of caspase (SMAC)-mimetic compound that promotes degradation of cIAP-1 and releases active caspases from XIAP inhibitory binding, as a radiosensitizing agent in HNSCC cells.We found that SM-164 at nanomolar concentrations induced radiosensitization in some HNSCC cell lines in a manner dependent on intrinsic sensitivity to caspase activation and apoptosis induction.
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