【摘 要】
：
Microglia are central nervous system (CNS)-resident macrophages and they play important roles in neural development and function.Recent studies have suggest
【机 构】
：
Professor,DivisionofLifeScience,TheHongKongUniversityofScienceandTechnology,HongKong
论文部分内容阅读
Microglia are central nervous system (CNS)-resident macrophages and they play important roles in neural development and function.Recent studies have suggested that murine microglia arise from a single source, the yolk sac (YS), yet these studies lack spatial resolution to define the bona fide source(s) for microglia.Here, using a light-induced high temporal-spatial resolution fate mapping, we challenge this single source view by showing that microglia in zebrafish arise from multiple sources.The embryonic/larval microglia originate from the rostral blood island (RBI) region, the equivalent of mouse YS for myelopoiesis, whereas the adult microglia arise from the ventral wall of dorsal aorta (VDA) region, a tissue also producing definitive hematopoiesis in mouse.We further show that the VDA region-derived microglia are Runx1-depedent but cMyb-independent, and are developmentally regulated differently from the RBI region-derived microglia.Our study establishes a new paradigm for investigating the development and function of distinct microglia populations.
其他文献
The CRISPR/Cas9 system has recently been developed as a powerful and flexible technology for different purposes of targeted genome engineering, including ge
It is a routine task in metabolic engineering to introduce multicomponent pathways into a heterologous host for production of metabolites.However, this proc
Imbalances in gene expression of a metabolic pathway can result in less-yield of the desired products.Several targets were intensively investigated to balan
An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeab
Insulators are non-coding gene regulatory elements in genome, which function as chromatin partitioning boundaries, and block interference across different c
Activation of cryptic gene clusters in Streptomycetes requires a diversity of well-characterized regulatory elements.For characterizing the regulatory eleme
Bone Morphogenetic Protein (BMP) signaling regulates diverse biological processes.During vascular development, we and others have shown that BMP signaling p
The Notch signaling pathway has been demonstrated to play critical roles during development by specifying cell fates.In this study, we show that Notch signa
The Proliferation and differentiation of adult stem/progenitor cells into specific lineages should be precisely regulated during organ development.Hippo pat
Stable localization of signaling complex is essential for robust morphogenesis of polarized cells.Cell elongation involves molecular signaling centers which