Restoring masticatory functions,phonetics,deglutition and nasal regurgitation of oral intakes are challenging problems to overcome for hemimaxillectomy patients.A definitive solution for such surgery is the fabrication of prosthesis that improvises the impression procedures to accommodate the dimensional changes of the tissues and utilizes a two stage denture issuance technique.The 1st stage includes chair-side soft auto-polymerizing resin material over hollow bulb obturator denture issuance.Upon recall verifying the dimensional changes,2nd functional impression is recorded using the previously issued denture as a special tray.Permanent processed soft tissue conditioner is used as liner over the hollow-bulb obturator denture as final issued definitive and retentive prosthesis for 2nd stage denture issuance.Two stage denture issuance technique to fabricate a retentive,stable and functional prosthesis for hemimaxillectomy patients with soft tissue liner material minimize dimensional changes of the soft tissue.The defect sealing by the denture to the defect is improved and soft denture liner provides conditioning to the underlying tissues.