Tissue-specific roles of CGI-58, an intracellular lipolytic activator, in the pathogenesis of metabo

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：wangsong1008

【摘要】

：

Mutations in human Comparative Gene Identification-58 (CGI-58, also known as Abhd5) gene cause a neutral lipid storage disease characterized by intracellular ac

【作者】

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Liqing Yu

【机构】

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DepartmentofAnimalandAvianSciences,UniversityofMaryland,CollegePark

【出处】

：

2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

：

2014年10期

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Mutations in human Comparative Gene Identification-58 (CGI-58, also known as Abhd5) gene cause a neutral lipid storage disease characterized by intracellular accumulation of lipid droplets in most cells except fat.In vitro studies have shown that CGI-58 activates the activity of Adipose Triglyceride Lipase (ATGL) to promote the breakdown of cytosolic lipid droplets.However, CGI-58 clearly has ATGL-independent functions that are currently unknown.

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Tissue-specific roles of CGI-58, an intracellular lipolytic activator, in the pathogenesis of metabo

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