【摘 要】
:
Objective: To investigate the therapeutic efficiency of dasatinib in CML patients with mutations ofimatinib-resistant ABL kinase domains.Methods: We report two cases of CML patients who were resistant
【机 构】
:
Department of Hematology,The First Affiliated Hospital of Nanjing Medical University,Jiangsu Provinc
【出 处】
:
22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To investigate the therapeutic efficiency of dasatinib in CML patients with mutations ofimatinib-resistant ABL kinase domains.Methods: We report two cases of CML patients who were resistant to imatinib and nilotinib, but not to dasatinib, because of ABL mutation.ABL kinase domains were sequenced.Theeffectiveness of dasatinib administration was determined.
其他文献
Objective: To explore the morbidity, clinical features, treatment,and prognostic factors of primary cutaneous B-cell lymphoma(PCBCL).Methods: A total of 31 patients with PCBCL were registered in Tianj
Objective: To explore the morbidity, clinical features,metastasis, treatment, and prognostic factors of leg-type primary cutaneous diffuse large B-cell lymphoma (PCLBCL).Methods: Four patients with le
Objective: To determine the effect of FoxM1 downregulation on curcumin-induced growth and angiogenesis inhibition of acute myeloid leukemia (AML) cells.Methods: The inhibitory effects of curcumin were
Objective: To determine the function of IL-9 in the development of CLL through STAT3, STAT6/miR-155, and miR-21 pathways.Methods: Data of patients who were diagnosed with CLL at Shandong Provincial Ho
Objective: To investigate the expression of metadherin(MTDH) in chronic lymphocytic leukemia (CLL) and its role in regulating the Wnt signaling pathway.Methods: Using an EDTA anticoagulant tube, venou
Objective: To explore the prognostic significance of NPM1,CEBPA, FLT3-ITD, and C-KIT gene mutations in normal karyotype (NK-AML).Methods: Bone marrow (BM) samples were collected from116 patients with
Objective: This study aims to evaluate the possible synergistic effects between γδT cells and bortezomib, as well as to determine the underlying mechanism.Methods: The proliferation of U266 cells [mul
Objective: To analyze retrospectively the safety and efficacy of myeloablative conditioning regimen without anti-thymocyte globulin (ATG) and total body irradiation (TBI), but with fludarabine (FLU) i
Objective: This study aims to discuss the treatment strategiesand curative effect of removing the compression symptoms from the lymphoma of patients with superior vena cava syndrome(SVCS).Methods: A t
Objective: The effectiveness ofgemcitabine in treating refractory or relapse non-Hodgkin lymphoma was retrospectively analyzed.Methods: A total of 53 refractory or relapsed lymphoma patients who recei