Objective: In conditions of modern activity the problem of diagnosis and treatment of sexual dysfunction in men is very important.This is due to the lack of consensus on the definition of premature ejaculation(PE).A sufficiently high degree of subjectivity in the evaluation of patients of their condition makes it necessary quantification of symptoms on a scale scoring system.By focusing on the symptoms of sexual dysfunction,it is important to determine the scoring system,through which they can identify and trace the progression of the disease,to evaluate the effectiveness of various therapeutic agents and compare them.To determine the sensitivity to changes adapted version of the questionnaire UIPE.Methods: The study involved 37 patients with premature ejaculation,diagnosed with the help of the adapted version of the questionnaire UIPE and objective research methods [intravaginal ejaculation latency time(IELT)and International Index of Erectile Function(IIEF-5)].The subjects have consented in writing to the combined conservative treatment of premature ejaculation by drugs from the group of selective serotonin reuptake inhibitors(SSRI)and inhibitors of phosphodiesterase type 5(PDE-5).The age of patients who agreed to undergo combined medicamentous therapy of PE ranged from 22 to 66 years(mean age,34.9±1.4 years).Patients were offered a combination treatment with fluoxetine and tadalafil.Fluoxetine was administered at 20 mg(1 capsule)1 a day in the afternoon,after 6 pm,1 hour after meals,tadalafil-20 mg(1 tablet)a day,in the afternoon,after 6:00 evening,1 hour before anticipated sexual intercourse.The course of recommended treatment was on 2 months.After 2 months,the patients were again asked to answer questionnaire UIPE.Results: Results were estimated by using numerical indicators UIPE(scores)IELT(minutes)and IIEF-5(scores).At the end of treatment score UIPE index decreased by 67.5%(from baseline 25.6±0.6 to 8.3±0.5;P<0.01),IELT index improved to 5.25 times(from baseline 1.2±0.1 to 6.3±0.2;P<0.01),IIEF index remained practically unchanged-5(the initial value 22.0±0.2 to 23.0±0.2;P>0.05).The results of evaluation of performance monitoring in patients after combined fluoxetine and tadalafil demonstrate a significant decrease of UIPE index and an increase IELT patients compared to baseline values.This indicated an improvement in the condition of patients on the background of a combined medical therapy,manifested by increasing of IELT.it should be noted that the rate of fluoxetine on the background of tadalafil does not cause side effects in the form of erectile dysfunction.Conclusions: The UIPE questionnaire has a high degree of sensitivity to changes,and can be used to assess the effectiveness of treatment of patients with premature ejaculation.