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Purpose A case of splenosis confirmed histopathologically was provided,to offer information for radiologists to distinguish splenosis from other abdominal lesions. Methods We present a case of perihepatic and omental lesions,some of those lesions were resected and confirmed pathologically as splenosis. Result A 44-year-old man was referred for evaluation of hepatic mass and omental nodules detected incidently on a routine physical examination.The patient`s laboratory test results are within normal ranges.The patient had a past medical history of a splenectomy after trauma 20 years ago.Unenhanced CT revealed a 3.5cm x 2.8cm x 2.8cm solid mass,with homogeneous hypodensity compared with adjacent liver parenchyma.After administration of contrast agent,the mass showed a mild enhancement on the arterial phase,moderate enhancement on the portal venous phase and delayed hepatocyte phase.The lesion located in a subcuapsular position,in close proximity to right diaphragm,with slight compression and displacement of adjacent liver,but did not distinctively appear to arise from the liver.Multiple nodules,with varying sizes(the biggest one measuring 3.0cm x 2.0cm x 2.7cm),were also found to be scattered along omenta,and all nodules demonstrated moderate homogeneous enhancement after administration of contrast agent.Due to diagnostician`s lack of experience,the diagnosis of hepatic malignancy with omental metastases was considered.To define the status of lesions,the patient and his families chose surgery.During operation,the mass was found to locate between right liver and diaphragm,deep dent on the surface of right liver was seen.Two of the largest lesions along omenta also were resected.Based on the histopathological findings of three lesions as normal spleen tissue and the patient`s history of splenectomy,the diagnosis of intra-abdominal splenosis was made. Conclusion In summary,for patients with a history of splenic trauma or splenectomy,if abdominal mass presented,abdominal splenosis should be included in the differential diagnosis.