SKP2 is the substrate recognition subunit of the SCFSKP2 ubiquitin ligase complex.It is implicated in ubiquitin-mediated degradation of the cyclin dependent kinase (CDK) inhibitor p27KIP1, and positiv
We analyzed the differential effects of histopathology, induction of apoptosis and radiation response gene expression after acute low dose rate (LDR) and chronic high dose rate (HDR) radiation exposur
A large number of patients are treated in various countries with traditional radon spa therapy.Many clinical studies have been reported, but no data are available explaining why radon inhalation resul
XRCC4-deficient (XRCC4-/-) cells generated by a gene targeting exhibit a lower survival rate and a higher frequency of chromosomal aberrations than parental HCT 116 cells after exposure to ionizing ra
Objective of this research was studying influence of various concentration of a dust of uranium ore (DUO) on animals in condition of lipid peroxidation (LP).
Associations of ionizing radiation (IR) and cancer risks in uranium mining and nuclear industry were published earlier.The action of high doses of IR also well investigated.
Although mutations and deletions of the p53 tumor suppressor gene lead to resistance to low linear energy transfer (LET) radiation, high LET radiation efficiently induces cell lethality and apoptosis
Induction of adaptive response (AR) by combination of irradiations with different LET values was attempted in a series of investigations in young adult female mice of C57BL/6J strain using mainly thir
Purpose/objectives: Normal lung tissue tolerance constitutes a limiting factor in delivering a required radiation dose.The biological effects of high precision particle therapy with protons or carbon