【摘 要】
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Enabling nanocarriers to complete the sophisticated journey from the initial injection site to the targeted tumor cells and achieve "spatiotemporally pinpointed" drug release intracellularly is a chal
【机 构】
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Department of Polymer Science and Technology,Key Laboratory of Systems Bioengineering of the Ministr
【出 处】
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中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
论文部分内容阅读
Enabling nanocarriers to complete the sophisticated journey from the initial injection site to the targeted tumor cells and achieve "spatiotemporally pinpointed" drug release intracellularly is a challenging task in anticancer drug delivery.Therefore,the optimal structure design of nanocarriers is necessary to inhibit premature release of anticancer drugs from nanocarriers during blood circulation and improve drug release inside tumor cells.Herein,two pathways to fabricate core or shell cross-linked polymer micelles by combining reduction and pH sensitive cleavable bonds coordinately were introduced.
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