Background:Treatment of implanted pacemaker or artificial blood vessel is saving lives for severe arrhythmia or abdominal aortic aneurysm in patients with serious cardiovascular disease.But as with all of the artificial material implantation in the human body, the infection is a serious complication.Plastic surgeons have expertise in the treatment of various chronic wound, in recent years more and more patients with refractory wounds following a referral by other departments to treatment of plastic surgery.Treatment of complex chronic wound infection induced cardiovascular surgical implants is a new challenge to plastic surgeons.Methods: The two patients were referral from the department of cardiology inour hospital.One case is the recurrent peptic ulceration caused by chest skin infection after pacemaker implantation, and the other one is the abdominal aortic aneurysm after artificial vascular bypass surgery on both sides of the groin area refractory wound.Debridement was performed accompanying withnegative pressure wound therapy for more than 10 days and continuousirrigation;In the postoperative Phase thickness and split-thickness skin grafting was used for surgery after wound bed preparation, and accompanying with continuous negative pressure ventilation treatment in skin grafting area.Results: 2 patients recovering well from surgery, wounds healed well.Conclusion: Irrigation is still the most effective means for infected wounds.All kinds of negative pressure wound therapy for refractory wounds is a conventional means;while in the clinical application process,minor treatments such as deep with drainage to facilitate washing and other techniques which can be applied combined according to the treatment needs to improve the therapeutic effect.