【摘 要】
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The challenge, following the sequencing of the human genome, is the functional decryption of the human proteome.Specific binders to every human protein are
【机 构】
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Technische Universit(a)t Braunschweig Institut für Biochemie und Biotechnologie Germany
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The challenge, following the sequencing of the human genome, is the functional decryption of the human proteome.Specific binders to every human protein are key reagents for this purpose.In vitro antibody selection with antibody phage display offers a solution that can meet this gargantuan demand for 25.000 or more antibodies.For this purpose three human, naive antibody gene libraries (HAL4/7/8) were constructed and a high-throughput compatible antibody selection pipeline was set up.The quality of the libraries and the selection pipeline was validated with more than 100 antigens, including human, other mammalian, fungal or bacterial proteins, viruses or haptens.Furthermore, examples for the application of recombinant antibodies from this pipeline for diagnostics and therapy are given.
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