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In rabbits and rats with hemorrhagic and traumatic shock (TSh) there is a decrease in the level of glucocorticoid receptors (GR).Reduction in the GR content occurs simultaneously with more than 2-fold elevation of corticosteron concentration in blood plasma.These data suggest the existence of relative glucocorticoid insufficiency in animals with shock.Suppression of GR is caused by hypoxia and not by immobilization stress.Decrease in GR level could be induced by short periodic exposures to hypoxia.After preexposure of rats to hypoxic conditions there was also more pronounced reduction in GR content during shock and deterioration of shock process.