【摘 要】
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Depression is a leading cause of disability worldwide.However the biological and molecular mechanisms underlying this disorder remain to be unknown.Stress is a disposing factor in the development of d
【机 构】
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State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia
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Depression is a leading cause of disability worldwide.However the biological and molecular mechanisms underlying this disorder remain to be unknown.Stress is a disposing factor in the development of depression, which could lead to HPA axis activation and the release of glucocorticoids.Glucocorticoids have two receptors, one is GR, the other is MR.Despite the fact that GR has been extensively studied, there is increasingly awareness that MR has a crucial role in the development of depression.This review summarizes how the MR plays a role in the pathophysiology of depression in HPA axis regulation, inflammation, neurogenesis as well as stressrelated behaviors.Considering that the research about MR in the development of depression is limited, further investigation of MR is needed for better understanding of this disease, which could contribute to the prevention and treatment of depressive disorder.
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