【摘 要】
：
Many furan-containing compounds have been reported to be toxic and/or carcinogenic.Furanoids occur in a wide range of fruits, herbs, foods, and beverages.Th
【机 构】
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School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110015, China
【出 处】
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2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Many furan-containing compounds have been reported to be toxic and/or carcinogenic.Furanoids occur in a wide range of fruits, herbs, foods, and beverages.The demand to identify harmful furans potentially ingested has been increasing, due to the rapidly growing global interest in the use of natural products as medical remedies, dietary supplements, and 'natural' foods.The objectives of the study were to develop an analytical platform to screen cis-enediones resulting from metabolic activation of potentially harmful furans and establish a method to investigate their potential for protein modification in vitro and in vivo.2,5-dimethylfuran (DMF), a model furanoid, was incubated with rat liver microsomes supplemented with glutathione (GSH) and 4-bromobenzylamine (BBA) as trapping agents, followed by LC-MS/MS analysis.
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