新肺炎链球菌毒力因子GHIA三维结构与功能研究

来源 :2012全国临床微生物与感染免疫学术研讨会 | 被引量 : 0次 | 上传用户:zq20081979
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  肺炎 链球菌(Streptococcus pneumoniae,S.pn)是严重侵袭性感染和上呼吸道感染最重要的病原体之一,可导致肺炎、脑膜炎、中耳炎和脓毒血症等.目前全球每年死于肺炎链球菌感染的总人数高达300万至500万人,儿童和60岁以上患者是高危人群.抗生素和疫苗是人类抗击S.pn的主要手段,但目前S.pn肺炎链球菌的耐药率持续增加,现有疫苗的保护效果也不甚理想.因此要有效解决S.pn感染的预防和治疗,需要进一步了解其致病分子机制,寻找新的毒力因子作为药物作用靶点和疫苗开发的依据.
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