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Gliomas,with which patients have a median survival of only 15 months are the most common and aggressive central nervous system(CNS)cancers of adults.Due to the inherent infiltrative,complete remove of gliomas through surgical resection remains a great challenge.Magnetic resonance imaging(MRI)using Gd-based contrast agents have been widely used in the diagnosis of brain tumors.However,the short blood half-life which require high dosages and the nephrogenic systemic fibrosis may restrict the application.Recently,our group put forward a high-resolution imaging strategy to track the nanosized extracellular microvesicles within the whole-body of nude mouse in a real-time and quantitative manner by using ultrasmall Mn-magnetofunctionalized Ag2Se quantum dots(Ag2Se@Mn QDs).