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  5. Parallel Computational Protein Design

Parallel Computational Protein Design

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：lianlianforever
【摘 要】
：
Motivation: Structure-based computational protein design is an important topic in protein engineering.Under the assumption of a rigid backbone and a finite set of discrete conformations of side-chains
【作 者】
：
周弈超 徐葳 Bruce R.Donald 曾坚阳 
【机 构】
：
交叉信息研究院,清华大学,北京,100084 计算机科学系,杜克大学,德拉姆,北卡,27708;生
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
Protein design parallel computation A* tree search dead-end elimination (DEE) GP 
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　　Motivation: Structure-based computational protein design is an important topic in protein engineering.Under the assumption of a rigid backbone and a finite set of discrete conformations of side-chains, various methods have been proposed to address this problem.A popular method is to combine the dead-end elimination (DEE) and A* tree search algorithms, which provably finds the Global Minimum Energy Conformation (GMEC) solution.
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