论文部分内容阅读
The ATM protein kinase is implicated in the DNA damage response and in sensing DNA double strand breaks.However, recent observations have involved ATM in non-nuclear pathways.ATM belongs to the PIKK family, which includes also mTOR, DNA-PK and ATR.Despite their diverse biological roles, these kinases share a similar structure characterized by the presence of a PI3K domain in the C-terminus and an N-terminal portion composed of interspersed HEAT repeat units.We recently showed that ATR mediates a response to mechanical stress by relocating at the nuclear envelope.