Transmissible spongiform encephalopathies (TSEs) are a group of infectious fatal neurodegenerative diseases, and prion protein is the key factor in TSEs.The
A hallmark of a group of neurodegenerative diseases such as Alzheimer disease is the formation of neurofibrillary tangles which are principally composed of
Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thou
Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD 1), is a fatal degenerat
Amyloidosis occurs in a crowded and confined environment in vivo, which contains polysaccharides, proteins, and nucleic acid.Some previous reports have show
Most lipases contain a lid domain to shield the hydrophobic binding site from the water environment.The lid, mostly in helical form, can undergo a conformat
Cystatins are important natural cysteine protease inhibitors (CPIs).The cysteine proteases include C1 family (papain-like) and C 13 family (legumains).The C