Bacterial resistance has become a serious threat to human health.Research to discover antibacterial agents with novel mechanisms of action is of great importance.In this study,eleven series of chalcon
Carfilzomib,a structural analogue derived from natural product epoxomicin that wasapproved by US FDA for the treatment of relapsed and refractory multiple myeloma[1-3].
A new series of multitarget-directed edaravone derivatives were designed and synthesized.Rational pharmcophore-directed design strategy was undertaken and antioxidant edaravone was combined with the a
Increaseing HIF-1α levels after ischemic stroke cells can protect damaged nerves,reduce disability mortality.HIF-1α is ubiquitinated and degradated by the von Hippel-Lindau protein(pVHL).However,the s