Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carniv

来源 :2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议 | 被引量 : 0次 | 上传用户:aglusaiy
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It has been believed that the RNASE1 gene duplications are correlated with the plant-feeding adaptation of foregut-fermenting herbivores.Here, we characterized RNASE1 genes from Caniformia, which has a simple digestive system, based on both gene sequence and tissue expression analyses.The results yielded new hypotheses regarding the evolution and the function of Caniformia RNASE1 genes.Our study rejects previous Mustelidae-specific duplication hypothesis, but supporting Musteloidea duplication hypothesis.Moreover, our analyses revealed pronounced differences among the RNASE1 gene copies regarding their selection pressures, pI values and tissue expression patterns.The present work demonstrated a far more complex and intriguing evolutionary pattern and functional diversity of mammalian ribonuclease than previously thought.
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