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BACKGROUND: Atherosclerosis (AS) is associated with cerebrovascular events.It is well-established that AS is a systematic disease involving multiple vascular beds simultaneously.Previous studies have shown that the coexisting AS at intracranial and extracranial vascular territories is common in patients with stroke.However, the correlation of AS between intracranial and extracranial arteries has not been well studied.The purpose of this research was to investigate the correlation of atherosclerotic disease between extracranial and intracranial carotid arteries in symptomatic patients.