Amphiphilic molecule generally contains a hydrophilic part and a hydrophobic part,which are linked by covalent bonding[1].The special amphiphilic feature drives the molecules to self-assemble into well-defined nanostructures in aqueous solution,such as micelles and vesicles,which can present great application in biomedical field such as drug delivery[2].However,how to introduce mutli-stimuli responsiveness into the amphiphilic molecule is a key issue for obtaining a smart drug delivery system.