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Objective To study the association between obstructive sleep apneahypopnea syndrome (OSAHS) and pulmonary thromboembolism (PTE), and the effect of OSAHS on the dose of warfarin used in anticoagulant therapy in patient with PTE.Methods The study selected the total of 100 PTE patients hospitalized in the Department of Respiratory Medicine of Capital Medical University affiliated Beijing Anzhen Hospital from 2007 to 2012.The patients were divided into two groups according to polysomnography or Berlin Questionnaire: OSAHS group (n=34) and non-OSAHS group (n=66).The following indexes were analyzed in both groups: age, body mass index (BMI), smoking history ,diabetes mellitus,total cholesterol (TC), plasma triglycerides(TG),erythrocyte,hemoglobin and platelet, c-reactive protein and PO2 and PCO2 the blood gas analysis without administration of oxygen.,Intemational Normalized Ratio(INR) and the dose of warfarin when left hospital.Results OSAHS group and without OSAHS group has differents in sex, BMI,history of diabetes(p<0.05).TG and PCO2 of the OSAHS group are different from non-OSAHS group(p <0.05).The group which had a bigger dose of warfarin when left hospital was OSAHS group (OSAHS group vs non-OSAHS group: (5.534±1.44) mg vs (4.19±1.26) mg, p<0.05).While there are no different in other test index.Logistic study suggest that male, obesity or overweight, diabetes are the influence factors ofOSAHS (p<0.05).Conclusion OSAHS is associated with PTE risk factors, which may be the reason why OSAHS patients has higher occurrence rate of the PTE.In addition, OSAHS patients can increase the dose of warfarin for PTE patients who need to anticoagulant therapy.