Alzheimer's disease (AD), which accounts for 60%to 70%of cases of dementia, has been puzzling doctors and scientists all over the world.As the unknown of pathogenesis and mechanism of AD, there is no efficient treatment so far.In 2006, the appearance of induced pluripotent stem cells (iPSCs) provides a new way for exploring the mechanism and treatment of many diseases, including AD.There was a number of studies show that iPSCs-derived neural cells were able to express some phenotypes related to Alzheimer' s disease.It indicates that iPSCs could be a promising cell model for AD' s mechanism study and drug screening.Plus, because using homogenous cells canavoidthe immune repulsioncaused by xenogenous transplantation, these cells derived from patient' s iPSCs mayeven serve as a new resource of stem cell transplantation.In this study, we obtained iPSCsand neural cells from 3 patients with typical sporadic Alzheimer' s disease (sAD), and explored the pathological markers and transplantation potentials of iPSC-derived neural cells and NSCs.As a result, we found that 1) there was no abnormal secretion of Aβ and tau in neural cells differentiated from both patients and non-demented controls;2) after 7 days of transplantation, the NSCs from these patients successfully survived and integrated into rat brains.These results indicated that cells differentiated from thesesAD patients do not have significant differences compared to normal people, and bear the potential value for cell replacement therapy.