Phosphorylation and inactivation of phosphatase and tensin homolog at residues Ser380Thr382383 induc

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户:HYB1976
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Phosphorylation of phosphatase and tensin homolog (PTEN) at residues Ser380/Thr382/383 is an important post-translational modification, which results in the loss of tumor suppressor function and increased cancer susceptibility.To better understand the role of this phosphorylation in gastric cancer development, PTEN phosphorylation and protein levels were examined in gastric cancer tissues, and in tissue specimens of various stages of gastric carcinogenesis using Western blot and immunohistochemistry.
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