【摘 要】
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Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimers disease (AD).Aβ is generated from amyloid-β precursor protein (APP) through sequ
【机 构】
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Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Pharmace
【出 处】
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华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimers disease (AD).Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase.Inhibiting β-secretase activity is believed to be one of the most promising strategies for AD treatment.
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