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Objective: To evaluate the role of three-dimensional radiotherapy for Non-Small Cell Lung Cancer (NSCLC)patients with bone metastasis.Methods: Clinical data of 95 NSCLC patients with bone metastases were collected.All patients received radiation to the thoracic primary tumor and ≥2 cycles of chemotherapy.The Kaplan-Meier method was used to calculate overall survival (OS).The log-rank test was used to compare the survival curves.The multivariate Cox regression model was used to test independent significant prognostic factors for OS.