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目的：研究长期给予普萘洛尔是否对被动吸烟诱导的COPD 大鼠肺及心脏有保护作用，研究动物模型中普萘洛尔干预后心肺组织基质金属蛋白酶2、9 (MMP-2、9)，组织金属蛋白酶抑制剂1(TIMP-1)及胶原Ⅰ、Ⅲ(Col-Ⅰ、Ⅲ的变化。
长期给予普萘洛尔对被动吸烟大鼠心肺组织基质金属蛋白酶及胶原表达的影响
【摘 要】
：
目的：研究长期给予普萘洛尔是否对被动吸烟诱导的COPD 大鼠肺及心脏有保护作用，研究动物模型中普萘洛尔干预后心肺组织基质金属蛋白酶2、9 (MMP-2、9)，组织金属蛋白酶抑制剂1(TIMP-1)及胶原Ⅰ、Ⅲ(Col-Ⅰ、Ⅲ的变化。
【机 构】
：
北京大学第三医院呼吸科,北京 100191 北京大学第三医院血管医学研究所,北京 100191
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
【发表日期】
：
2014年7期
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