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目的:观察分析过敏性紫癜(HSP)患儿血浆细胞因子白细胞介素(IL)-6、8、10和肿瘤坏死因子α(TNF-α)水平对病情预后即肾损害和紫癜复发的影响。方法:回顾性分析2010～2011年HSP不同预后的56例患儿,将其分为对照组(HSP患儿无复发及肾炎,31例)、紫癜性肾炎组(HSPN,20例)、复发组(即在随访1年内发生紫癜复发但未出现HSPN,5例),进行相关分析。结果:HSPN组和复发组的血清IL-6、IL-8值均高于对照组(P<0.05),该两组组间比较无差异(P>0.05)。HSPN组的IL-10值高于对照组和复发组(P<0.05),后两者组间比较并无统计学差异(P>0.05)。复发组TNF-α值高于对照组(P<0.05);HSPN组与对照组、复发组比较无差异(P>0.05)。讨论:血清IL-6、IL-8、IL-10值对监测HSP病情的发展及预后具有显著临床意义。
OBJECTIVE: To observe the effect of plasma levels of interleukin-6, 8, 10 and tumor necrosis factor-α (TNF-α) on the prognosis of patients with Henoch-Schonlein purpura (HSP), ie, renal damage and purpura recurrence. Methods: 56 children with different prognosis of HSP from 2010 to 2011 were retrospectively analyzed. They were divided into control group (31 cases without recurrence and nephritis, 24 cases with HSPN, 20 cases with recurrent disease) (Ie, purpura recurrence occurred within 1 year but did not appear in HSPN, 5 cases), the correlation analysis. Results: Serum levels of IL-6 and IL-8 in HSPN group and relapsed group were significantly higher than those in control group (P <0.05). There was no significant difference between the two groups (P> 0.05). The level of IL-10 in HSPN group was higher than that in control group and recurrent group (P <0.05). There was no significant difference between the two groups (P> 0.05). TNF-α in relapse group was higher than that in control group (P <0.05). There was no difference between HSPN group and control group and recurrence group (P> 0.05). Discussion: Serum IL-6, IL-8 and IL-10 levels have significant clinical significance in monitoring the progression and prognosis of HSP.