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Purpose: To obtain a pH-responsive Doxorubicin drug delivery system.Methods: A novel and well-defined pH-triggered backbone-cleavable triblock copolymer was successfully synthesized by hydroxyethyl terminal with oxime linked poly(ethylene glycol)(OAPEGOH)ligating with polycaprolactone(PCL).And the triblock copolymer was characterized using fourier transformed infrared spectroscopy(FTIR),nuclear magnetic resonance(NMR),and gel permeation chromatography(GPC)analysis.Doxorubicin(DOX),a model anticancer drug,was encapsulated into PCL-PEG-PCL micelles.