抗组织纤维化双靶点(TGF-β1和Cox-2)小核酸新药在小鼠、猪和人皮肤瘢痕组织中的应用

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：jizhe1983621

【摘要】

：

外科手术和自身创伤所造成的皮肤过度瘢痕是目前临床面临的一个极具挑战性的问题.增生性瘢痕是机体创伤修复过程中炎症反应和组织再生的必然产物.STP705以组氨酸赖氨酸共聚物

【作者】

：

石静丽周佳 Vera Simonenko 王志远徐军路阳李青峰陆阳

【机构】

：

苏州圣诺生物医药技术有限公司

【出处】

：

第五届中国小核酸技术与应用学术会议

【发表日期】

：

2015年9期

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论文部分内容阅读

外科手术和自身创伤所造成的皮肤过度瘢痕是目前临床面临的一个极具挑战性的问题.增生性瘢痕是机体创伤修复过程中炎症反应和组织再生的必然产物.STP705以组氨酸赖氨酸共聚物作为载体,增强双靶点小核酸进入体内的效率,可以沉默TGF-β1和COX-2两种基因的表达,这两个基因在机体异常纤维化和炎症介质中起关键调节作用.

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抗组织纤维化双靶点(TGF-β1和Cox-2)小核酸新药在小鼠、猪和人皮肤瘢痕组织中的应用

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