Bilogical nanomotors powered by energy-rich molecules have been evolved over millions of years-these bio-nanomachines support life on Earth.We live in the era of machines miniaturization and the idea of self-propelled nanosubmarine was speculated long time ago during the birth ofnanotechnology field.A three-dimensional nanomembrane technology was developed by Schmidt[l] and Mei.[2] Multifunctional rolled-up micro-and nanotubes can be mass-produced and offer many novel technologically relevant and important breakthroughs in diverse research areas."The smallest man-made jet engine"(Guinness World Record)based on rolled-up chemically actuated catalytic nanomembranes was demonstrated in our group.These engineered catalytic micro-and nanojet engines,powered by catalytic decomposition of hydrogen peroxide into microbubbles and water,are able to self-propel ultra-fast at a low Reynolds number[3] and accomplish multiple tasks.[4] Collective and swarming catalytic microengines pave the way towards more sophisticated multiconstituent micromachines with interactive moving parts.[5] Recent exciting developments and prototype applications of man-made micro-and nanomachines suggest that we are on the way to discover tomorrows multipurpose nanomachines for realization of myriad of useful tasks for humanity,such as autonomous pumping of fluids,transport of cargo on-chip,roving biosensors,delivery of medicine to a target site,remote-controlled nanosurgery,environmental remediation,sequestration and conversion of greenhouse emission gases.This presentation will discuss concepts,challenges and perspectives of man-made micro-and nanomachines,their technological relevancy and important breakthroughs.