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蛋白酪氨酸磷酸酯酶1B(protein tyrosine phosphatase 1B,PTP1B)在胰岛素和瘦素信号通路中起着重要的双重负调控作用,是治疗2型糖尿病及其综合征的潜在靶标。虽然PTP1B抑制剂的研究成为热点,但是至今没有成功上市的药物。
基于虚拟筛选的新型PTP1B抑制剂的发现
【摘 要】
：
蛋白酪氨酸磷酸酯酶1B(protein tyrosine phosphatase 1B,PTP1B)在胰岛素和瘦素信号通路中起着重要的双重负调控作用,是治疗2型糖尿病及其综合征的潜在靶标。虽然PTP1B抑制剂的研究成为热点,但是至今没有成功上市的药物。
【机 构】
：
中国医学科学院药物研究所,北京,100050
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
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