岩藻糖基化GP73在肝细胞癌诊断中的应用价值

来源 :第十七届全国临床肿瘤学大会暨2014年CSCO学术年会 | 被引量 : 0次 | 上传用户:kunhodde
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背景:甲胎蛋白(AFP)用于检测原发性肝癌(hepatocellular carcinoma,HCC)具有较高的敏感性和特异性,但仍有1/3左右的患者呈阴性.因此,寻求敏感性和特异性更高的新型肿瘤标志物,对于提高HCC的诊断准确率以制定有效的治疗策略具有重要的意义.核心岩藻糖基化被认为是糖蛋白糖链合成的终末反应,可参与构成某些重要黏附分子的糖链结构,在肿瘤发生、发展方面起重要作用.
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