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  5. Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity i

Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity i

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：flscut
【摘 要】
：
Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor and plays an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons.Whether IGF-1 influences growth-associated
【作 者】
：
Zhen Liu Zhenzhong Li 
【机 构】
：
Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China
【出 处】
：
The 18th Congress of the International Federation of Associa
【发表日期】
：
2014年8期
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Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor and plays an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons.Whether IGF-1 influences growth-associated protein 43 (GAP-43) expression and activates the extracellular signal-regulated protein kinase (ERK1/2) and the phosphatidylinositol 3-kinase (PI3K)/Akt pathways in DRG neurons with excitotoxicity induced by glutamate (Glu) is still unclear.
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