【摘 要】
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Parkinsons disease (PD) is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta (SNpc).The mainly characteristic is
【机 构】
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Laboratory of Physical Biology,Shanghai Institute of Applied Physics,CAS,Shanghai,China;University o
【出 处】
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8th IUPAP International Conference on Biological Physics(第八届
论文部分内容阅读
Parkinsons disease (PD) is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta (SNpc).The mainly characteristic is the aggregation of the alpha synuclein (α-syn).Some research indicated that the aggregated α-syn is related with the metal ion level in the brain, especially iron, copper and zinc[1-3].Rapamycin is usually used asanimmunosuppressive agents.In 1-methyl-4-phenyl-l,2,3,6-terahydropyridine (MPTP)-treated mouse model of PD, rapamycin can protect dopaminergic (DA) neurons against MPTP, but the mechanism therein remains unknown.In our study, we used synchrotron radiation X-ray fluorescence (SRXRF) to examine the metal ion level in the brain section of each groups mouse.We found that mouse in MPTP group had a higher level of copper and zinc accompanying with the aggregation of α-syn in SNpc compared with mouse in saline group.After treated the mouse with rapamycin, the aggregation of α-syn was inhibited and the level of copper and zinc was also reduced.The results prompted that the protective effect of rapamycin in MPTP-induced mouse possible through regulating the metal homeostasis in the brain.
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