【摘 要】
：
The identification of a sensitive and specific serum marker will facilitate the early diagnosis ofhepatocellular carcinoma (HCC) and increase patient surviv
【机 构】
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CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Phys
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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The identification of a sensitive and specific serum marker will facilitate the early diagnosis ofhepatocellular carcinoma (HCC) and increase patient survival rates.In this study, bile fluid from 82 patients suffering from hepatic carcinoma (n=40), gall-stone (n=20), cystic polypi (n=15) and hepatic benign lesions (n=7) were analyzed through a high-efficient Ultra Performance Liquid Chromatography (UPLC) mass spectrometry metabolic profiling strategy.The acquired data were subjected to orthogonal signal correction-partial least squares discriminate analysis (OSC-PLSDA) to extract the significant bile fluid components that played a key role in defining the disease state.
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