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Type I interferons (IFNs) play a key role for the antiviral state of host but porcine reproductive and respiratory syndrome virus (PRRSV) has been shown to down-regulate the production of IFNs during infection.Non-structural protein (nsp) 1 of PRRSV has been identified as a viral antagonist for IFN production,and subsequently the nspl-alpha subunit of nspl has been shown to degrade the CREB (cyclic AMP responsive element binding)-binding protein (CBP).CBP is a major component of the IFN enhanceosome,and thus the CBP degradation inhibits the formation of enhanceosome resulting in the suppression of IFN gene expression.